HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-(2-Fluoro-4-nitrophenyl)pyrrolidin-2-yl)methanol → 1-(2-Fluoro-4-nitro-phenyl)-pyrrolidine-2-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-(2-Fluoro-4-nitrophenyl)pyrrolidin-2-yl)methanol | HCID 18416155 | — |
| Reactant | Dess-Martin Periodate | HCID 131723735 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(2-Fluoro-4-nitro-phenyl)-pyrrolidine-2-carbaldehyde | HCID 59300360 | — |
Reaction Steps
[1-(2-Fluoro-4-nitro-phenyl)-pyrrolidin-2-yl]-methanol (100 mg, 0.42 mmol) and Dess-Martin periodate (175 mg, 0.42 mmol) is stirred in CH2Cl2 overnight. After chromatography, the desired product is isolated (100 mg, ˜100%): 1H NMR (300 MHz, CDCl3) 9.67 (1H, s), 7.85-7.98 (2H, m), 6.66 (1H, t, J=9.0 Hz), 4.65-4.72 (1H, m), 3.49-3.75 (2H, m), 1.89-2.30 (4H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-0eaa6f865b714d319dd3fe90b4e96bb4 |
| Source note | uspto-grants-2010_05 |