HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → [1-(2-Fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl]-dimethyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 1-(2-Fluoro-4-nitro-phenyl)-pyrrolidine-2-carbaldehyde | HCID 59300360 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [1-(2-Fluoro-4-nitro-phenyl)-pyrrolidin-2-ylmethyl]-dimethyl-amine | HCID 59300313 | 69% |
Reaction Steps
1-(2-Fluoro-4-nitro-phenyl)-pyrrolidine-2-carbaldehyde (100 mg, 0.42 mmol) and dimethylamine (large excess) is stirred at room temperature in CH2Cl2 for 5 min and NaBH(OAc)3 (120 mg, 0.57 mmol) is added. The reaction is stopped after 30 min as TLC suggested complete conversion and the desired product (77 mg, 69%) is isolated after chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-b2bba44e5e5b409faf366d48089cc8eb |
| Source note | uspto-grants-2010_05 |