HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-(5-nitropyridin-2-yl)piperazine → 6-(4-Methylpiperazin-1-yl)pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-(5-nitropyridin-2-yl)piperazine | HCID 2764066 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-(4-Methylpiperazin-1-yl)pyridin-3-amine | HCID 2763390 | 104.5% |
Reaction Steps
An amount of 1 g (4.48 mmol) of 1-Methyl-4-(5-nitro-pyridin-2-yl)-piperazine is dissolved in methanol (50 mL), followed by a catalytic amount of 10% Pd/C. The mixture is hydrogenated at 35-40 psi for 3 hours, filtrated through celite followed by evaporation to give 900 mg (100% yield) of purple solid; mp 97-98° C. MS (ESI) m/z 193.1 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-ed8c7d9ac2184ac3901354ddfd7d627b |
| Source note | uspto-grants-2010_05 |