4-(Morpholinomethyl)aniline → 4-(Pyridin-2-ylmethoxy)aniline

HRID 2236526Notes

Reaction equation

HRID 2236526 reaction equation
N1(CC2C=CC(N)=CC=2)CCOCC1.[N+:15]([C:18]1[CH:31]=[CH:30][C:21]([O:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)=[CH:20][CH:19]=1)([O-])=O>>[N:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[CH2:23][O:22][C:21]1[CH:30]=[CH:31][C:18]([NH2:15])=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 7768514-(Morpholinomethyl)anilineHCID 8209312-[(4-Nitrophenoxy)methyl]pyridine

Product 1

HCID 104427734-(Pyridin-2-ylmethoxy)anilineYield 100%

Procedure

Using the procedure described for the preparation of 4-Morpholin-4-ylmethyl-phenylamine, 1.16 g (100%) of white crystals is obtained from 1.5 g (5.55 mmol) of ′2-[(4-nitrophenoxy)methyl]pyridine; mp 50-51° C. MS (ESI) m/z 201.1 (M+1)+.

Sources & evidence

ORD record
ord-b2a3fbfb990b44a88fbb7659b5f206c1
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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