Potassium Carbonate → Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate

Participants

Reaction Conditions

Reaction Steps

A mixture of 3 g (14.78 mmol) of 5-bromo-2-nitropyridine, 5.5 g (29.56 mmol) of tert-butyl 1-piperazinecarboxylate, 5.46 g (14.78 mmol) of tetra-butylammonium iodine and 4.1 g (29.56 mmol) of potassium carbonate were placed in a flask. Dimethylsulfoxide (45 mL) is added and heat up to 80° C. for 24 hours. After cooling to room temperature, the precipitate is filtered and washed with ethyl acetate. Excess amount of water is added and extracted 4×. Dried with sodium sulfate and evaporated to give 2.7 g (59% yield) as a yellow solid. MS (ESI) m/z 309.1(M+1)

Provenance & Evidence