反应详情

A mixture of chloro-(4-methoxy-5-nitro-pyridin-2-yl)-acetic acid tert-butyl ester (2.98 g, 9.84 mole) and acetic acid (25 mL) is refluxed for 6 hours, cooled and evaporated. The residue is dissolved in dichloromethane, passed thru a pad of magnesol, evaporated to dryness and crystallized from 3:1 hexanes/ethyl acetate to give a light yellow solid, 1.78 g, (89%); MS (ES+): m/z 203.2, 205.2 (M+H).

1. temperatureis refluxed for 6 hours
2. temperaturecooled
3. customevaporated
4. dissolutionThe residue is dissolved in dichloromethane
5. customevaporated to dryness
6. customcrystallized from 3:1 hexanes/ethyl acetate
7. customto give a light yellow solid, 1.78 g, (89%)