HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichlorobenzene → 2-Methylisoquinoline-1,3(2H,4H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichlorobenzene | HCID 7239 | — |
| Reactant | HCID 19845561 | HCID 19845561 | — |
| Product | 2-Methylisoquinoline-1,3(2H,4H)-dione | HCID 349436 | — |
Reaction Steps
A mixture of 2.28 g (11.8 mmol) of N-methyl-(2-carboxybenzeneacetamide and 24 ml of 1,2-dichlorobenzene is refluxed for 1 h and evaporated to dryness. The residue is recrystallized from EtOAc-hexane to give an off-white solid, 1.55 g (75%), mp 113-115° C.; MS (ES+) m/z 176.1 (M+H)+1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-838fec8717644b59b3a4f1c9067029ed |
| Source note | uspto-grants-2010_05 |