反应详情

An amount of 3-hydroxy-4-(2-methoxyethoxy)benzaldehyde (1.24 g, 6.32 mmol) in 20 mL of EtOH and 10 mL of pyridine is added methoxy]amine hydrochloride (1.06 g, 12.64 mmol). The reaction mixture is stirred at room temperature over weekend. Solvent is removed under vacuum to give colorless oil which is added ether, washed twice with saturated NaHCO3 solution, once with brine, dried over Mg2SO4, filtered and evaporated to give colorless oil. Leaving this oil overnight at room temperature gave 1.15 g (81.0% yield) of colorless solid: mp: 63-64° C.; MS (ESI) m/z 226.1 (M+H)+1

1. customSolvent is removed under vacuum
2. customto give colorless oil which
3. washwashed twice with saturated NaHCO3 solution, once with brine
4. dry with materialdried over Mg2SO4
5. filtrationfiltered
6. customevaporated
7. customto give colorless oil
8. customLeaving this oil overnight at room temperature