HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2236583Generated: October 26, 2026
(4E)-4-[(Dimethylamino)methylene]-1,4-dihydro-3(2H)-isoquinolinone → HCID 178517432, compound
https://huagongshe.com/reaction/2236583
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (4E)-4-[(Dimethylamino)methylene]-1,4-dihydro-3(2H)-isoquinolinone | HCID 68694591 | — |
| Reactant | HCID 178507418 | HCID 178507418 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 178517432 | HCID 178517432 | 28% |
Reaction Steps
A toluene (3 mL) solution containing (4E)-4-[(dimethylamino)methylene]-1,4-dihydro-3(2H)-isoquinolinone (300 mg, 1.48 mmol) and 4-(1H-imidazol-4-yl)aniline (265 mg, 1.66 mmol) is heated at 110° C. for 4 h. Using the same workup as example 1, 0.13 g (28%) orange solid is obtained: mp 151-152° C. (dec.); HRMS (ESI) m/z calcd for C19H16N4O 317.13969. found 317.13894 (M+H)+1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07713994B2 |
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| Source dataset | uspto-grants-2010_05 |
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| ORD ID | ord-1fe117cb5b84433cb6c1d42db61f50f8 |
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| Source note | uspto-grants-2010_05 |
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