4-(4-Methylpiperazin-1-yl)aniline → HCID 86619578, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-methoxymethylene-4H-isoquinoline-1,3-dione (101.5 mg, 0.5 mmol), 4-(4-methyl-piperazin-1-yl)-phenylamine (95.6 mg, 0.5 mmol) in 1 mL of N,N-dimethylformamide is heated at 110° C. for 1 h. After cooling in the refrigerator, the precipitate is collected, and washed with ether to give 163 mg (90%) of yellow solid mp 245-246° C.; MS (ESI) m/z 363.19 (M+1); Analysis for C21H22N4O2: Calcd: C, 69.59; H, 6.12; N, 15.46. Found: C, 69.49; H, 6.10; N, 15.36.

Provenance & Evidence