4-(Piperidin-1-ylmethyl)aniline → HCID 178518323, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-methoxymethylene-4H-isoquinoline-1,3-dione (101.5 mg, 0.5 mmol), 4-piperidin-1-ylmethyl-phenylamine (95.14 mg, 0.5 mmol) in 1 mL of N,N-dimethylformamide is heated at 110° C. for 2 h. After cooling in the refrigerator, the precipitate is collected, and washed with ether to give 92 mg (51%) of yellow solid mp 185-186° C.; HRMS (ESI) m/z calcd for C22H23N3O2 362.18546. found 362.18631 (M+H)+1.

Provenance & Evidence