4-(Morpholinomethyl)aniline → HCID 178518325, compound

HRID 2236591Notes

Reaction equation

HRID 2236591 reaction equation
CO/[CH:3]=[C:4]1/[C:5](=[O:15])[NH:6][C:7](=[O:14])[C:8]2[C:13]/1=[CH:12][CH:11]=[CH:10][CH:9]=2.[N:16]1([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=2)[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>>[N:16]1([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([NH:29]/[CH:3]=[C:4]3\[C:5](=[O:15])[NH:6][C:7](=[O:14])[C:8]4[C:13]\3=[CH:12][CH:11]=[CH:10][CH:9]=4)=[CH:25][CH:24]=2)[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 7768514-(Morpholinomethyl)anilineHCID 59300321(4E)-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

Product 1

HCID 178518325HCID 178518325, compoundYield 18.7%

Procedure

Using the procedure described for the preparation of example 14, 100 mg (15% yield) of a yellow solid from 300 mg (1.47 mmol) of (4E)-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione and 4-morpholin-4-ylmethyl-phenylamine 283.5 mg (1.47 mmol); mp 221-2MS (ESI) m/z 463.1 (M−1).

Sources & evidence

ORD record
ord-7f80131f42094b4fb2344349b06de2e2
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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