Tryptamine → HCID 178518284, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (124.5 mg, 0.44 mmol), tryptamine (70.7 mg, 0.44 mmol) in 1 mL of N,N-dimethylformamide is heated at 110° C. for 1.5 h. After cooling in the refrigerator, the precipitate is collected, and washed with ether to give 100 mg (55%) of yellow solid mp 278-280° C.; HRMS (ESI) m/z calcd for C20H16BrN3O2 408.03531. found 408.03493 (M+H)+1, Analysis for C20H16BrN3O2; Calcd: C, 58.55; H, 3.93; N, 10.24. Found: C, 58.34; H, 3.63; N, 10.21.

Provenance & Evidence