Acetyl chloride → HCID 178475407, compound

Participants

Reaction Steps

A solution of 4Z)-4-{[(3,4-dihydroxybenzyl)amino]methylene}-isoquinoline-1,3(2H,4H)-dione, (0.2 g, 0.644 mmol) in 0.27 mL (1.93 mmol) of triethylamine and 5 mL of pyridine is stirred at room temperature for 10 min, then 0.1 mL (1.42 mmol) of acetyl chloride is added. The reaction mixture is stirred at room temperature under N2 for 3 h. After evaporating the solvent, the residue is dissolved in dichloromethane, washed twice with water, dried over Mg2SO4, filtered and concentrated to give yellow solid. Recrystallized in EtOAc/Hex to afford 0.28 g (65.1% yield) of light yellow solid: mp 184-186° C.; MS (ESI) m/z 395.3 (M+H)+1, Analysis for C21H18N2O6. Calcd: C, 63.96; H, 4.60; N, 7.10. Found: C, 63.56; H, 4.69; N, 6.72.

Provenance & Evidence