Dimethylformamide → HCID 178507569, compound

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Reaction Steps

A mixture of 6-bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (141 mg, 0.5 mmol), 4-(4-methyl-piperazin-1-yl)-phenylamine (61.1 mg, 0.5 mmol) in 1 mL of N,N-dimethylformamide is stirred at room temperature for 40 min. After cooling in the refrigerator, the precipitate is collected, and washed with ether to give 61 mg (33%) of yellow solid mp 214-215° C.; HRMS (ESI) m/z calcd for C17H14BrN3O2 370.01966. found 370.01900 (M+H)−1, Analysis for C17H14BrN3O2 (0.33H2O); Calcd: C, 53.98; H, 3.91; N, 11.11. Found: C, 54.07; H, 3.52; N, 10.91.

Provenance & Evidence