O-Methylhydroxylamine hydrochloride → (4Z)-6-(3-Furyl)-4-{[(3-hydroxy-4,5-dimethoxybenzyl)amino)methylene}isoquinoline

Participants

Reaction Steps

Using the procedure described for the preparation of example 46, 120 mg of brown solid (50%) yield is obtained from 150 mg (0.57 mmol) of (4E)-6-(3-furyl)methoxymethylene-isoquinoline-1,3(2H,4H-dione, (prepared similarly to 4-methoxymethylene-6-thiophin-3-yl-isoquinolin-(4H)-1,3-dione) and 3-hydroxy-4,5-dimethoxybenzylamine (115 mg, 0.57 mmol), (prepared similarly to (4E)-6,7-dimethoxy-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione and 3-hydroxy-4-methoxy-benzylamine hydrogen chloride, except methoxy amine hydrogen chloride is used instead of hydroxylamine hydrogen chloride); mp 263-264° C.

Provenance & Evidence