Aniline → HCID 178518382, compound

HRID 2236617Notes

Reaction equation

HRID 2236617 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])[C:5]2=[CH:14][NH:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[CH:18][CH:17]=1.[NH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[NH:29]([C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\[NH:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[CH:18][CH:17]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 1785182616-bromo-4-[[4-(piperidin-1-ylmethyl)anilino]methylidene]isoquinoline-1,3-dione

Product 1

HCID 178518382HCID 178518382, compound

Procedure

Using the procedure described for the preparation of example 118, the title compound is obtained as yellow solid (70% yield) from 6-bromo-4-[(4-piperidin-1-ylmethyl-phenylamino)-methylene]-4H-isoquinoline-1,3-dione and aniline.

Workup

  1. customdescribed for the preparation of example 118

Sources & evidence

ORD record
ord-4872ada4c7354c11b7cbb8f1bfc78962
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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