4-(4-Methylpiperazin-1-yl)aniline → HCID 178480745, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-methoxymethylene-6-(2-morpholin-4-yl-ethoxy)-4H-isoquinoline-1,3-dione (115 mg, 0.35 mmole), N,N-dimethylformamide (1 mL) and 4-(4-methyl-piperazin-1-yl)-phenylamine (66 mg, 0.35 mmole) is stirred and heated at 110° C. for one hour, cooled in the refrigerator. The reaction mixture is evaporated to dryness, taken up in 5% methanol in chloroform and passed through a short pad of Florisil eluting with 5% methanol in chloroform. The eluate is evaporated in vacuo and treated with ether, filtered and dried to give a yellow solid 72 mg (42%), mp 142-143° C.; MS (ES+): m/z 492.2 (M+H).

Provenance & Evidence