Iodoethane → HCID 178466594, compound

Participants

Reaction Steps

To a solution of 1-iodoethane (43.3 μl, 0.28 mmol) in anhydrous N,N-dimethylformamide (2 ML) is added potassium carbonate (207 mg, 1.5 mmol). The mixture stirred at room temperature and (4Z)-6-bromo-4-{[(3,4-dihydroxybenzyl)amino]methylene} isoquinoline-1,3(2H,4H)-dione (100 mg, 0.26 mmol) is added. After the mixture is stirred at 65° C. for 30 min, the resulting mixture is concentrated and the residue is then partitioned between water (50 ml) and ethyl acetate (50 ml). The organic layer is then dried and purified by high performance liquid chromatography to give 26 mg of a white solid. MS (ESI) m/z 416.7 (M+1).

Provenance & Evidence