4-(2-(Pyrrolidin-1-yl)ethyl)aniline → HCID 178518257, compound

Participants

Reaction Steps

A solution of 0.300 g (1.06 mmol) of 6-bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione and 0.222 g (1.17 mmol) of 4-(2-pyrrolidin-1-yl-ethyl)-phenylamine in 1.8 mL of N,N-dimethylformamide (DMF) is heated at 120° C. for 1 h. The reaction is placed in a freezer and the precipitated material is collected, washed with cold N,N-dimethylformamide (DMF) (2×), cold MeOH (2×) and Et2O and dried in vacuo to give 0.307 g (66%) of brick red crystals: mp 212-214° C. (dec);

Provenance & Evidence