Triethylamine → HCID 86619583, compound

Participants

Reaction Steps

An amount of 90 mg (0.40 mmol) of 4-difluoromethoxy-3-hydroxy benzylamine hydrochloride, is dissolved in N,N-dimethylformamide (4 mL). 50 ul (0.75 mmol) of triethylamine is added followed by 112 mg (0.40 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione. After the mixture is stirred at room temperature for 30 min, the solvent is removed in-vacuo and the residue dissolved in 7.5% methanol in chloroform and passed thru a short pad of Florisil eluting with 7.5% methanol in chloroform, the eluate is evaporated and the solid triturated with ether, filtered and washed several times with anhydrous ether to give 116 mg of a pink solid (67% yield); mp 256-8° C., MS data ES(−) 437.0, 439.0 (M−1).

Provenance & Evidence