Sodium Carbonate → HCID 86619584, compound

Participants

Reaction Steps

An amount of (4Z)-6-bromo-4-{[(3-hydroxy-4-propoxybenzyl)amino]methylene}isoquinoline}-1,3(2H,4H)-dione (135.0 mg, 0.32 mmol) is dissolved in 80% mixture of N,N dimethylformamide/water (4 mL). Tetrakistriphenylphosphine (44.0 mg, 0.04 mmol) is added followed by 3-thiopheneboronic acid (48.4 mg, 0.38 mmol) along with sodium carbonate (67.8 mg, 0.64 mmol). The reaction mixture is heated to 150° C.-180° C. for 3 minutes under microwave irradiation. The solvent is concentrated and the reaction mixture is partitioned between ethyl acetate (50 ml) and water (50 ml). The crude solid is then purified by high performance liquid chromatography to give 25.0 mg of a white solid. MS (ESI) m/z 549.8 (M+1).

Provenance & Evidence