1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 42625428, compound

Participants

Reaction Conditions

Reaction Steps

To a 0° C. mixture of crude 1-(3-benzyloxy-4-methoxy-phenyl)-ethanol (10 mmol maximum) and diphenylphosphoryl azide (2.6 mL, 12 mmol) in toluene (18 mL) is added 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU, 1.6 mL, 11 mmol). The mixture is stirred at 0° C. for two hours and then at room temperature overnight. The reaction mixture is washed with water and concentrated to give 4-(1-azido-ethyl)-2-benzyloxy-1-methoxybenzene, which is used in the next step without purification.

Provenance & Evidence