Potassium Carbonate → HCID 178458731, compound

Participants

Reaction Conditions

Reaction Steps

(4Z)-6-bromo-4-{[(3,5-dihydroxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione (50 mg, 0.128 mmol) is dissolved in 1 mL N,N-dimethylformamide (DMF) (1 mL). To the resulting solution is added 1-iodo-propane (25 μL, 0.256 mmol) and K2CO3 (53 mg, 0.384 mmol). The reaction mixture is heated at 100° C. for 2 hours. The solid is filtered and purified by HPLC eluting with 20% CH3CN/H2O to 100% CH3CN over 30 minutes to give 19 mg (34%) of the title compound as a tan powder. MS (ESI) m/z 431.1(M+H)+

Provenance & Evidence