4-Nitrophenyl chloroformate → HCID 178480742, compound

Participants

Reaction Steps

An amount of 200 mg (0.53 mmol) of (4Z)-6-amino-4-({[4-(4-methylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione and 4-nitrophenyl chloroformate 320.0 mg (1.59 mmol) is stirred in N,N-dimethylacetamide at 100° C. for 1 hour. After cooling, the solvent is evaporated and stirred in 3 mL of water for 10 minutes. The solid precipitate is collected with ether to give 180 mg (70% yield) of (4-{[4(4-methyl-piperazin-1-yl)-phenylamino]-methylene}-1,3-dioxo-1,2,3,4-tetrahyro-isoquinolin-6-yl)-carbamic acid 4-nitro-phenyl ester.

Provenance & Evidence