Water → HCID 178507736, compound

Participants

Reaction Steps

6-Bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (124 mg, 0.44 mmol), 3-amino-5-aminomethyl-benzene-1,2-diol dihydrochloride salt (100 mg, 0.44 mmol) and Et3N (0.15 mL, 1.1 mmol) in N,N-dimethylformamide (DMF) (5 mL) is stirred at 25° C. for 24 hours. Water (10 mL) is added to the reaction mixture. The resulting solid is filtered and washed with water. The crude solid is purified by HPLC, eluting with 20% CH3CN/H2O to 100% CH3CN over 30 minutes to give 51 mg (22%) of the title compound as a brown solid. HRMS (ESI) m/z calcd for C17H14BrN3O4 (M+H)+ 404.02405. found: 404.02336.

Provenance & Evidence