Water → HCID 178458507, compound

Participants

Reaction Steps

6-Bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (110 mg, 0.39 mmol), 5-aminomethyl-2,3-dipropoxy-phenol hydrochloride salt (93 mg, 0.39 mmol) and Et3N (112 μL, 0.8 mmol) in N,N-dimethylformamide (DMF) (2 mL) is stirred at 25° C. for 24 hours. H2O (10 mL) is added to the reaction mixture. The resulting precipitate is filtered, washed with H2O and dried in vacuo to give 170 mg (91%) of the title compound as a tan powder. HRMS (ESI) m/z calcd for C23H25BrN2O5 (M+H)+1 489.10196. found: 489.10078.

Provenance & Evidence