Triethylamine → HCID 178483974, compound

Participants

Reaction Steps

(4E)-6-Bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione (0.21 g, 0.76 mmol) and 4-(2-dimethylamino-ethylsulfanyl)-phenylamine (0.15 g, 0.76 mmol) were stirred in N,N-dimethylformamide (5 mL) and triethylamine (0.3 mL) at 60-70° C. for 5 minutes and then at room temperature for 10 minutes. The reaction mixture is quenched by the addition of water. The solid material is then collected, washed with diethyl ether, water, and methanol, and then dried under vacuum to give (4Z)-6-bromo-4-{[(4-{[2-(dimethylamino)ethyl]thio}phenyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione (0.22 mg, 65%) as a golden powder.

Provenance & Evidence