HCID 178429948, compound → 4-(3,5-Dimethylpiperazin-1-yl)aniline

HRID 2236699Notes

Reaction equation

HRID 2236699 reaction equation
[CH3:1][CH:2]1[NH:7][CH:6]([CH3:8])[CH2:5][N:4]([C:9]2[CH:14]=[CH:13][C:12]([NH:15]/[CH:16]=[C:17]3\[C:18](=[O:31])[NH:19][C:20](=[O:30])[C:21]4[C:26]\3=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][CH:22]=4)=[CH:11][CH:10]=2)[CH2:3]1.BrC1C=C2C(=CC=1)[C:39](=[O:43])NC(=O)C2=CNC1C=CC(N2CC(C)NC(C)C2)=CC=1>>[CH3:39][O:43][CH:16]=[C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([N+:27]([O-:29])=[O:28])[CH:25]=2)[C:20](=[O:30])[NH:19][C:18]1=[O:31].[CH3:8][CH:6]1[NH:7][CH:2]([CH3:1])[CH2:3][N:4]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH2:5]1

Participants

4

Reactant 2

HCID 178429948HCID 178429948, compoundHCID 178429952HCID 178429952, compound

Product 2

HCID 176054784-(3,5-Dimethylpiperazin-1-yl)anilineHCID 686944684-methoxymethylene-6-nitro-4H-isoquinoline-1,3-dione

Procedure

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 0.032 g (12.8% yield) of dark brown solid is obtained from 0.15 g (0.60 mmol) of 4-methoxymethylene-6-nitro-4H-isoquinoline-1,3-dione and [4-(3,5-dimethylpiperazin-1-yl)phenyl]amine (0.15 g, 0.72 mmol): mp >300° C.; MS (ESI) m/z 422.2 (M+H)+1

Sources & evidence

ORD record
ord-6fca0ab0460b4a958b32bc2910648ca7
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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