反应详情

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, after purified using silica gel chromatography (using 5% MeOH/CHCl3 as solvent), 0.68 g (91.0% yield) of light brown solid is obtained from 0.45 g (1.60 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione, and 0.38 g (1.76 mmol) of 4-(3,4,5-trimethyl-piperazin-1-yl)-phenylamine: mp 213-214° C.; MS (ESI) m/z 469.1-471.1 (M+H)+1

1. customafter purified