HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 178458434, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 5-(Aminomethyl)-2-propoxyphenol hydrochloride | HCID 42625832 | — |
| Reactant | (4E)-6-bromo-7-methoxy-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione | HCID 59300399 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 178458434 | HCID 178458434 | — |
Reaction Steps
A mixture of 5-Aminomethyl-2-propoxy-phenol hydrochloride (109 mg, 0.50 mmole), 4 mL of N,N-dimethylformamide and triethylamine (75 μL, x mmole) were stirred for 15 minutes. Then (4E)-6-bromo-7-methoxy-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione (156 mg, 0.50 mmole) is added and the reaction mixture stirred for one hour. The product is isolated as before, to give an off-white solid, 119 mg, (51%), mp 212-214° C. dec; MS (ESI): m/z 459.1, 461.2 (M−H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-341f2665d78941498790890080d789b0 |
| Source note | uspto-grants-2010_05 |