Dimethylformamide → HCID 178483391, compound

Participants

Reaction Steps

(4E)-6-Bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione (50 mg, 0.18 mmol) 4-(3-dimethylamino-propyl)-phenylamine hydrochloride (0.40 mmol) were stirred in N,N-dimethylformamide (1 mL) and triethylamine (140 μL) at 78° C. The reaction mixture is quenched by the addition of water. The solid material is then collected, washed with water, and then dried under vacuum to give (4Z)-6-bromo-4-[({4-[3-(dimethylamino)propyl]phenyl}amino)methylene]isoquinoline-1,3(2H,4H)-dione (58 mg, 75%) as a golden solid.

Provenance & Evidence