HCID 178429948, compound → (E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

HRID 2236745Notes

Reaction equation

HRID 2236745 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\NC1C=CC(CN2CCOCC2)=CC=1.BrC1C=C2C(=CC=1)[C:36](=[O:40])NC(=O)C2=CNC1C=CC(N2CC(C)NC(C)C2)=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]/[O:40][CH3:36]

Participants

3

Reactant 2

HCID 178429948HCID 178429948, compoundHCID 178518262HCID 178518262, compound

Product 1

HCID 68692760(E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

Procedure

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 5.11 g (81.9% yield) of yellow solid is obtained from 4.0 g (14.18 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione and 3.24 g (17.0 mmol) of 4-[(2-methylpyrrolidin-1-yl)methyl]phenyl}amine: mp 183-184° C.; MS (ESI) m/z 440.0 (M+H)+1

Sources & evidence

ORD record
ord-09be2504371b4dceaad64126dfc8f3f1
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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