tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate → HCID 178452237, compound

Participants

Reaction Steps

A N,N-dimethylformamide solution (2.2 mL) of 6-bromo-4-methoxymethylene-4H-isoquinoline-1,3-dione (280 mg, 0.99 mmol), and tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (300 mg, 1.08 mmol) is heated at 90° C. for 0.5 h. After cooling in the refrigerator, the precipitate is collected, and washed with N,N-dimethylformamide and ether to give 222 mg (42%) of the title compound as a yellow solid. MS (ESI) m/z 527.529 (M+H)+1

Provenance & Evidence