HCID 178429948, compound → 4-(Morpholinomethyl)aniline

HRID 2236750Notes

Reaction equation

HRID 2236750 reaction equation
[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\[NH:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[CH:18][CH:17]=1.BrC1C=C2C(=CC=1)[C:36](=[O:40])NC(=O)C2=CNC1C=CC(N2CC(C)NC(C)C2)=CC=1>>[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]/[O:40][CH3:36].[N:23]1([CH2:22][C:19]2[CH:20]=[CH:21][C:16]([NH2:15])=[CH:17][CH:18]=2)[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1

Participants

4

Reactant 2

HCID 178429948HCID 178429948, compoundHCID 178518344HCID 178518344, compound

Product 2

HCID 7768514-(Morpholinomethyl)anilineHCID 68691018(E)-6-iodo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

Procedure

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 0.27 g (91.0% yield) of tan solid is obtained from 0.20 g (0.608 mmol) of (4E)-6-iodo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione, and 0.14 g (0.608 mmol) of 4-Morpholin-4-ylmethyl-phenylamine: mp 186-187 oC; MS (ESI) m/z 490.1 (M+H)+1

Sources & evidence

ORD record
ord-4ac19038bbdc443e9e33759332c99fa7
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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