HRID2236784

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6049834

Crotonic anhydride

C8H10O3

$结构：CC(C)[Si](Oc1cc(CN/C=C2\C(=O)NC(=O)c3ccc(I)cc32)ccc1N)(C(C)C)C(C)C$

HCID178460972

未命名化合物

结构：O=C1NC(=O)c2ccc(I)cc2/C1=C/NCc1ccc(NC(=O)c2ccccc2)c(O)c1

HCID178518369

未命名化合物

PRODUCTS

生成物

$结构：C/C=C/C(=O)Nc1ccc(CN/C=C2\C(=O)NC(=O)c3ccc(I)cc32)cc1OC(=O)/C=C/C$

HCID178454465

未命名化合物

PROCEDURE

实验过程

Following the acetylation and desilylation procedure employed for the preparation of N-[2-hydroxy-4-({[(Z)-(6-iodo-1,3-dioxo-2,3-dihydroisoquinolin-4(1H)-ylidene)methyl]amino}methyl)phenyl]benzamide, (4Z)-4-[({4-amino-3-[(triisopropylsilyl)oxy]benzyl}amino)methylene]-6-iodoisoquinoline-1,3(2H,4H)-dione (65 mg, 0.11 mmol) is reacted with crotonic anhydride (49 μL, 0.33 mmol). Following desilylation and precipitation, 2-[(2E)-but-2-enoylamino]-5-({[(Z)-(6-iodo-1,3-dioxo-2,3-dihydroisoquinolin-4(1H)-ylidene)methyl]amino}methyl)phenyl (2E)-but-2-enoate is obtained (17 mg, 27%)

WORKUP

后处理

customdesilylation and precipitation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9e155bf3b7fd4db19f8a162d5d2abf03
来源数据集: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07713994B2
来源说明: uspto-grants-2010_05

反应 SMILES

[OH:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9]/[CH:10]=[C:11]2\[C:12](=[O:23])[NH:13][C:14](=[O:22])[C:15]3[C:20]\2=[CH:19][C:18]([I:21])=[CH:17][CH:16]=3)[CH:5]=[CH:4][C:3]=1[NH:24][C:25](=[O:32])[C:26]1C=CC=C[CH:27]=1.NC1C=CC(CN/C=C2\C(=O)N[C:44](=[O:52])[C:45]3C\2=CC(I)=[CH:47][CH:46]=3)=CC=1O[Si](C(C)C)(C(C)C)C(C)C.[C:67](OC(=O)/C=C/C)(=O)/C=C/C>>[C:44]([O:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9]/[CH:10]=[C:11]2\[C:12](=[O:23])[NH:13][C:14](=[O:22])[C:15]3[C:20]\2=[CH:19][C:18]([I:21])=[CH:17][CH:16]=3)[CH:5]=[CH:4][C:3]=1[NH:24][C:25](=[O:32])/[CH:26]=[CH:27]/[CH3:67])(=[O:52])/[CH:45]=[CH:46]/[CH3:47]