HCID 178429948, compound → HCID 3159809, compound

HRID 2236785Notes

Reaction equation

HRID 2236785 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\NC1C=CC(C2CCN(C)CC2)=CC=1.Br[C:30]1[CH:31]=[C:32]2C(=C[CH:39]=1)[C:36](=[O:40])NC(=O)[C:33]2=[CH:42][NH:43][C:44]1[CH:49]=[CH:48][C:47]([N:50]2CC(C)NC(C)C2)=[CH:46][CH:45]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]/[O:40][CH3:36].[CH3:39][CH:30]1[CH2:31][CH2:32][CH2:33][CH2:42][N:43]1[C:44]1[CH:49]=[CH:48][C:47]([NH2:50])=[CH:46][CH:45]=1

Participants

4

Reactant 2

HCID 178429948HCID 178429948, compoundHCID 178480193HCID 178480193, compound

Product 2

HCID 3159809HCID 3159809, compoundHCID 68692760(E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

Procedure

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione (24), 1.17 g (62.6% yield) of yellow solid is obtained from 1.2 g (4.25 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione and 0.97 g (5.10 mmol) of [4-(methylpiperidin-1-yl)phenyl]amine: mp 217-218° C.; MS (ESI) m/z 440.1-442.1 (M+H)+1

Sources & evidence

ORD record
ord-562e4cb323e444b49d775f93987ca4fb
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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