HCID 178429948, compound → (E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

Participants

Reaction Steps

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 1.87 g (72.2% yield) of light brown solid is obtained from 1.45 g (5.14 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione, and 1.3 g (5.14 mmol) of {3,5-difluoro-4-[(8aS)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]phenyl}amine: mp 190-191° C.; MS (ESI) m/z 503.1 (M+H)+1

Provenance & Evidence