HCID 178429948, compound → (E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

HRID 2236798Notes

Reaction equation

HRID 2236798 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\NC1C=CC(N2C[C@H](C)N[C@H](C)C2)=C(C(F)(F)F)C=1.BrC1C=C2C(=CC=1)[C:41](=[O:45])NC(=O)C2=CNC1C=CC(N2CC(C)NC(C)C2)=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]/[O:45][CH3:41]

Participants

3

Reactant 2

HCID 178429948HCID 178429948, compoundHCID 178461501HCID 178461501, compound

Product 1

HCID 68692760(E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

Procedure

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, \2.28 g (62% yield) of yellow solid is obtained from 2.0 g (7.0 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline 1,3(2H,4H)-dione, and 2.13 g (7.7 mmol) of 4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-(trifluoromethyl)phenyl]amine; mp: 224-225° C.; MS (ESI) m/z 523.1 (M+H)+1

Sources & evidence

ORD record
ord-9d211d5b037446aa9516318af78e1686
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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