tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate → HCID 178452239, compound

Participants

Reaction Steps

A N,N-dimethylformamide solution (2.2 mL) of 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (329 mg, 1 mmol), and tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (277 mg, 1 mmol) is heated at 90° C. for 0.5 h. After cooling in the refrigerator, the precipitate is collected, and washed with N,N-dimethylformamide and ether to give 423 mg (74%) of the title compound as a yellow solid. MS (ESI) m/z 575.2 (M+H)+1

Provenance & Evidence