Cesium carbonate → HCID 178462680, compound

Participants

Reaction Steps

(4Z)-4-({[6-(4-Ethylpiperazin-1-yl)pyridin-3-yl]amino}methylene)-6-iodoisoquinoline-1,3(2H,4H)-dione (50.3 mg, 0.1 mmol) is mixed with 3-furanboronic acid (22 mg, 0.2 mmol), Pd2(dba)3 (13.7 mg, 0.015 mmol), and cesium carbonate (65 mg, 0.2 mmol). After the solids were degassed, N,N-dimethylformamide (0.7 mL) and P(t-Bu)3 (6 mg, 0.03 mmol) were added. The mixture is heated at 100 C for 10 min, diluted with methylene chloride, and filtered. The filtrate is evaporated to dryness and purified by column chromatography to yield 30 mg (67%) of the title compound as an orange solid. MS (ESI) m/z 444 (M+H)+1

Provenance & Evidence