HCID 178429948, compound → (E)-6-iodo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

Participants

Reaction Steps

Using the procedure described for the preparation of 4Z)-6-bromo-4-({[4-(3,5-dimethylpiperazin-1-yl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione, 0.079 g (73.1% yield) of greenish tan solid is obtained from 0.064 g (0.19 mmol) of (4E)-6-iodo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione and 0.061 g (0.23 mmol) of (4-{1-[3-(dimethylamino)propyl]piperidin-4-yl}phenyl)amine: mp 139-140° C.; MS (ESI) m/z 559.0 (M+H)+1

Provenance & Evidence