HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → 1-(4-Amino-phenyl)-piperidine-4-carboxylic acid methoxy-methyl-amide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-methoxy-N-methyl-1-(4-nitrophenyl)piperidine-4-carboxamide | HCID 86098660 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | 1-(4-Amino-phenyl)-piperidine-4-carboxylic acid methoxy-methyl-amide dihydrochloride | HCID 87543017 | 100% |
Reaction Steps
A solution of 1-(4-nitro-phenyl)-piperidine-4-carboxylic acid methoxy-methyl-amide (approximately 0.20 g, 0.8 mmol) in ethanol/ethyl acetate (1:1, 30 mL) and concentrated hydrochloric acid (1 mL) is degassed with dry ice. Palladium on carbon (10%, 35 mg) is added and the mixture is shaken for two hours under 40 psi of hydrogen. The mixture is filtered through a pad of diatomaceous earth and concentrated under reduced pressure to give 1-(4-amino-phenyl)-piperidine-4-carboxylic acid methoxy-methyl-amide dihydrochloride (0.30 g, >100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-38616f058d0d4baf82f163be2244a000 |
| Source note | uspto-grants-2010_05 |