Dimethylformamide → HCID 178518378, compound

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	2-Amino-5-bromopyridine	HCID 70622	—
Reactant	(E)-4-(methoxymethylene)-6-(1H-pyrrol-1-yl)isoquinoline-1,3(2H,4H)-dione	HCID 59299993	—
Solvent	Diethyl Ether	HCID 3283	—
Product	HCID 178518378	HCID 178518378	—

Reaction Conditions

Temperature	125 °C

Reaction Steps

A mixture of (E)-4-(methoxymethylene)-6-(1H-pyrrol-1-yl)isoquinoline-1,3(2H,4H)-dione (268 mg, 1.0 mmole), dimethylformamide (8 mL), and 5-bromopyridin-2-amine (173 mg, 1.0 mmole) is heated at 125° C. for four hours. The reaction mixture is cooled, diluted with ether, filtered, washed with fresh ether and dried to give a salmon solid, 176 mg, (43%), mp 317-8° C. dec; MS (ES−): m/z 407.0 (M−H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07713994B2
Source dataset	uspto-grants-2010_05
ORD ID	ord-b85eb5e8ec8741bc9942fc68b3a1f76e
Source note	uspto-grants-2010_05