HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 178480146, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 5-(1-Methylpyrrolidin-2-yl)pyridin-2-amine | HCID 3110789 | — |
| Reactant | (E)-6-iodo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione | HCID 68691018 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 178480146 | HCID 178480146 | — |
Reaction Conditions
| Temperature | 125 °C |
|---|
Reaction Steps
A mixture of (E)-6-iodo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione (696 mg, 2.12 mmole), dimethylformamide (15 mL), and 5-(1-methylpyrrolidin-2-yl)pyridin-2-amine (375 mg, 2.12 mmole) is heated at 125° C. for four hours. The reaction mixture is cooled, diluted with ether, filtered, washed with fresh ether and dried to give a yellow solid, 580 mg, (58%), mp 174-206° C. dec; MS (ES+): m/z 475.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07713994B2 |
| Source dataset | uspto-grants-2010_05 |
| ORD ID | ord-d3bcbbc2082d406a8ded1dfe520e1a24 |
| Source note | uspto-grants-2010_05 |