3-Aminomethyl-4-furan-2-yl-phenol → HCID 178518374, compound

HRID 2236867Notes

Reaction equation

HRID 2236867 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])[CH:5]=[CH:4][C:3]=1C1C=CC=CC=1.IC1C=C2C(=CC=1)C(=O)N[C:35](=O)[C:34]2=[CH:43][O:44][CH3:45].NCC1C=C(O)C=CC=1C1OC=CC=1>>[O:44]1[CH:43]=[CH:34][CH:35]=[C:45]1[C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][C:6]=1[CH2:8][NH:9][CH:10]=[C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=2)[C:14](=[O:22])[NH:13][C:12]1=[O:23]

Participants

4

Reactant 3

HCID 592998373-Aminomethyl-4-furan-2-yl-phenolHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dioneHCID 178518360HCID 178518360, compound

Product 1

HCID 178518374HCID 178518374, compoundYield 56%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (100 mg, 0.30 mmol) and 3-Aminomethyl-4-furan-2-yl-phenol (crude material from the previous reaction in 56% yield: MS (ESI): 485.1 (M−1)−1.

Workup

  1. customfrom the previous reaction in 56% yield

Sources & evidence

ORD record
ord-7e31f5915728415e8a4d90b37256f104
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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