4-Aminomethyl-4'-fluoro-biphenyl-2-ol → 4-[[[4-(4-fluorophenyl)-3-hydroxyphenyl]methylamino]methylidene]-6-(furan-2-yl)isoquinoline-1,3-dione

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Reaction Steps

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-Furan-2-yl-4-methoxymethylene-4H-isoquinoline-1,3-dione (40 mg, 0.15 mmol) and 4-Aminomethyl-4′-fluoro-biphenyl-2-ol (33 mg, 0.15 mmol) in 62% yield: MS (ESI): 453.2 (M−1)−1.

Provenance & Evidence