5-Aminomethyl-2-furan-3-yl-phenol → HCID 178518364, compound

HRID 2236873Notes

Reaction equation

HRID 2236873 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])[CH:5]=[CH:4][C:3]=1[C:24]1[CH:29]=[CH:28][CH:27]=CC=1.IC1C=C2C(=CC=1)C(=[O:41])NC(=O)C2=COC.NCC1C=CC(C2C=COC=2)=C(O)C=1>>[O:41]1[CH:27]=[CH:28][CH:29]=[C:24]1[C:3]1[CH:4]=[CH:5][C:6]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])=[CH:7][C:2]=1[OH:1]

Participants

4

Reactant 3

HCID 426256705-Aminomethyl-2-furan-3-yl-phenolHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dioneHCID 178518360HCID 178518360, compound

Product 1

HCID 178518364HCID 178518364, compoundYield 53%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (80 mg, 0.24 mmol) and 5-Aminomethyl-2-furan-3-yl-phenol (50 mg, 0.26 mmol) in 53% yield: MS (ESI): 485.1 (M−1)−1.

Sources & evidence

ORD record
ord-d0c813bb5f894ffd9f5554cd3553f003
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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