4-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione → HCID 178518361, compound

HRID 2236875Notes

Reaction equation

HRID 2236875 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])[CH:5]=[CH:4][C:3]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26]C=1.IC1C=C2C(=CC=1)C(=O)[NH:36]C(=O)C2=COC.NCC1C=CC(C2C=CC=CN=2)=C(O)C=1>>[OH:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:36]=1)[CH2:8][NH:9][CH:10]=[C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=2)[C:14](=[O:22])[NH:13][C:12]1=[O:23]

Participants

4

Reactant 3

HCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dioneHCID 135922726HCID 135922726, compoundHCID 178518360HCID 178518360, compound

Product 1

HCID 178518361HCID 178518361, compoundYield 57%

Procedure

Following the same procedure for the preparation of 4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound is prepared from 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (98 mg, 0.30 mmol) and 5-Aminomethyl-2-pyridin-2-yl-phenol (60 mg, 0.30 mmol) in 57% yield: MS (ESI): 498.1 (M+1)+1.

Sources & evidence

ORD record
ord-32e0d924b06d4d198771aa9d813ae986
Source dataset
uspto-grants-2010_05
Patent number
US07713994B2

Reaction notes

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