4-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione → HCID 178458432, compound

Participants

Reaction Steps

A mixture of 6-aminomethyl-3-propoxy-pyridin-2-ol (91 mg, 0.50 mmole), 7 mL of N,N-dimethylformamide is stirred, then 4-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione (165 mg, 0.50 mmole) is added and the reaction mixture stirred for 4 hours. The reaction mixture is evaporated to dryness, triturated with 5% methanol in chlororform, filtered washed with fresh 5% methanol in chloroform, washed with acetonitrile and dried to give a beige solid, 152 mg, (63%);m.p. 275-81° C. dec; MS (ES +): m/z 478.1 (M+H).

Provenance & Evidence